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Nerve damage discovery linked to chemotherapy and possibly diabetes – this could lead to development of therapies to reverse the damage.

Nerve damage discovery linked to chemotherapy and possibly diabetes  – this could lead to development of therapies to reverse the damage.
Posted on May 05, 2016
Archive : May 2016
Category : News

Peripheral Neuropathy (Nerve damage) can occur as a result of diabetes, chemotherapy, traumatic injury and other conditions.

Symptoms can present themselves as a tingling sensation in the hands or feet and depending on the stage of the damage, can result in numbness in the hands and feet. Not being able to feel anything in these areas (especially in the feet which you cannot see easily) can result in damage to the skin, ulcer formation and potentially limb losing infections. In England alone, there are 135 amputations a week due to diabetes which may result from something as simple as not being able to feel a blister on your toe. Due to other complications associated with diabetes, if this ‘blister’ isn’t seen to straight away, it could ultimately result in an amputation.

Until now the mechanisms of this nerve damage has not been fully understood. As a result of this study which was carried out using Zebrafish larvae at MDI Biological Laboratory, Maine,USA, there is evidence of how, in the test cases, nerve damage was reversed and resultant skin damage from the damage improved. The test used a chemotherapy drug in its trials, but concluding that there is a common mechanism for some neuropathies affecting the sensory nervous system. This will allow researchers to work on developing therapeutic agents to reverse nerve damage linked to a range of conditions.


To find out more about this exciting development read the news article published here. 

The full findings are published in the Proceedings of the National Academy of Sciences.



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